Which category of medication indicates possible fetal risk in humans?

The correct answer is Category D, which indicates that there is evidence of fetal risk based on data from studies in humans. Medications classified under Category D have shown a risk to the fetus, but in some cases, the benefits of the medication may outweigh the potential risks. This category serves as a warning for prescribers to carefully consider the use of these medications in pregnant individuals, emphasizing the need for a thorough risk-benefit analysis before prescribing.

In contrast, Category A medications are considered safe for use in pregnant individuals, as studies have indicated no risk to the fetus. Category B indicates that animal studies have not shown harm to the fetus, but there are no well-controlled studies in humans. Category C includes medications that may have potential risks to the fetus but for which the benefits might justify their use in pregnant women. Each category is critical for guiding healthcare providers in making informed decisions regarding medication use during pregnancy, but only Category D explicitly highlights known risks to the fetus.